Dr. Mercola Interviews the Consultants
This text is a part of a weekly sequence wherein Dr. Mercola interviews varied specialists on a wide range of well being points. To see extra professional interviews, click on here.
On this interview, Stephanie Seneff, Ph.D., a senior analysis scientist at MIT, critiques the well being impacts of glyphosate. She has simply completed writing a guide about glyphosate referred to as “Toxic Legacy: How the Weedkiller Glyphosate is Destroying Our Well being and the Surroundings,” which is predicted to be revealed in June 2021.
For years, glyphosate was assumed protected and claims of toxicity had been vehemently denied. However in recent times, research on glyphosate have been demonstrating toxicity even at very low ranges. Seneff additionally believes glyphosate publicity could also be a key participant in circumstances of extreme COVID-19, which we’ll unravel on this interview.
Glyphosate’s Mechanism of Motion
The “gly” in glyphosate truly stands for the amino acid glycine. The glycine amino acid in glyphosate has a methylphosphonate group connected to its nitrogen atom, which is liable for its results and toxicity.
After finding out the analysis literature on glyphosate, Seneff has reached the conclusion that your physique typically substitutes glyphosate for the amino acid glycine when it’s establishing proteins, and this could have devastating penalties in some circumstances. The proteins created with glyphosate as a substitute of glycine merely don’t work as a result of glyphosate is way bigger than glycine and in addition negatively charged, and as a outcome this alters necessary bodily traits.
Monsanto’s personal analysis, relationship again to the late Nineteen Eighties, exhibits that glyphosate accumulates in varied tissues, even although they declare it doesn’t.1 The Monsanto researchers proposed that it was “integrated into” the proteins in the tissues. This isn’t broadly appreciated, even within the pure well being group.
Now, you probably have a distorted analog of glycine (within the type of glyphosate), the protein constructed from it just isn’t going to work prefer it’s imagined to. In her guide, Seneff particulars the amino acids in proteins which can be most prone to break due to what she calls a “glyphosate prone motif.”
“It’s actually fascinating biology and so terrifying whenever you assume of the potential penalties, if I am proper,” she says. “It matches so properly with all of the illnesses which can be going up dramatically in our society that I actually assume I am onto one thing big right here.”
An fragrant amino acid referred to as EPSP synthase is a vital enzyme that nearly absolutely will get disrupted by glyphosate by this mechanism of substituting for glycine. This will get a bit technical, however it will be important. The plant model of EPSP synthase binds a phosphate group in its substrate phosphoenolpyruvate at a website the place there’s a highly-conserved glycine residue (extremely conserved normally implies that it’s vital for correct perform).
It has been proven experimentally that, in the event you change the DNA code in order that the glycine is substituted by an amino acid referred to as alanine (one additional methyl group), the enzyme turns into fully insensitive to glyphosate at any focus. It additionally takes a success on phosphate binding due to the additional methyl group, however you’ll be able to tweak one other amino acid close by to repair this downside, whereas nonetheless conserving its insensitivity to glyphosate.
Researchers from Dow-Dupont did precisely this to a maize model of EPSP synthase utilizing CRISPR technology and had been in a position to create synthetically a model of the maize’s personal EPSP synthase that was fully immune to glyphosate. The title of this paper is: “Desensitizing Plant EPSP Synthase to Glyphosate: Optimized International Sequence Context Accommodates a Glycine-to-Alanine Change within the Lively Web site.”2
The shikimate pathway is the pathway that produces fragrant amino acids, that are important to people as we can not create these amino acids in our physique. The argument is we’re not prone to glyphosate as a result of our cells do not have EPSP synthase — in reality, they don’t have your entire shikimate pathway.
Nevertheless, our intestine microbes do have that pathway, they usually use it to make important amino acids for the host. So, our gut microbes are certainly affected by glyphosate, and after they’re broken, our well being can endure in any variety of methods.
However what is likely to be an much more devastating downside with glyphosate is the best way it most likely messes up a big variety of proteins that bind phosphate at a website the place there’s not less than one, and sometimes three, extremely conserved glycine residues. Glyphosate slips its methylphosphonate group into the spot that’s imagined to be the place phosphate from the substrate suits snugly. Phosphate can’t bind as a result of glyphosate is in the best way.
The arguments for why glyphosate particularly disrupts proteins that rely on glycine for phosphate binding are described extra absolutely in a paper Seneff revealed along with colleagues arguing that glyphosate is a significant component in kidney failure amongst younger agricultural staff in Central America.3
The Significance of Deuterium
Laszlo Boros is a professor of pediatrics at UCLA and an professional on deutenomics, “the science of autonomic deuterium discrimination in nature.”4 After studying one in every of Seneff’s papers, he contacted her, suggesting she look into deuterium.
“I used to be blown away, and I instantly noticed the connection to glyphosate,” she says. “This was a 12 months in the past in December, and I’ve simply been studying all the things I can on deuterium since then and hooking it to glyphosate. It is simply astonishing what I discovered, even, finally, [linking it] to COVID-19.
It has been fairly a 12 months for me by way of main breakthroughs in my understanding of how metabolism works and the way it’s getting tousled by glyphosate, after which how that is inflicting us to not give you the option to successfully take care of COVID-19.”
In regular physiology, your cells, particularly the mitochondria, perform to assist deplete your physique of deuterium. Deuterium is a naturally occurring isotope of hydrogen. Should you didn’t already know, deuterium is also called heavy hydrogen, as a result of it has a neutron in addition to the proton and electron within the hydrogen atom.
Offered your cell is wholesome, it has deuterium-depleting enzymes and organelles that assist take away deuterium out of your cells. In case your mitochondria are broken by glyphosate, they’re not going to have the ability to remove the deuterium correctly.
Deuterium is like iron in the best way that it’s each important in the appropriate quantities and poisonous in extra. Hydrogen is the smallest atom and by far the commonest atom in your physique. Deuterium, being a heavy hydrogen, has one additional neutron, along with the conventional proton and electron that common hydrogen has.
Now, your cells are surrounded by structured water, which is negatively charged and contributes to your physique’s power manufacturing by supplying deuterium-depleted hydrogen to lysosomes and mitochondria. The structured water is maintained by sulfates, which makes sulfate extraordinarily necessary for well being. Sulfate is made dysfunctional by glyphosate, which in flip destroys structured water, leading to impaired power manufacturing within the cell.5
“The mitochondria have [a] membrane, which has an element contained in the membrane that is actually, actually necessary,” Seneff says. “That is the place you might have these protons, and you actually don’t desire it to be deuterons. That is what Laszlo introduced dwelling to me.”
How Your Physique Creates Deuterium-Depleted Water
Endothelial NOS (eNOS) makes nitric oxide (NO), and for each molecule of NO that it makes, it produces two molecules of water, that are deuterium depleted. Stephanie believes the NO created by eNOS might act as a sign that deuterium-depleted water has been created. Apparently sufficient, deuterium-depleted water can also be created throughout the inflammatory course of.
“The irritation is there for a great purpose, and the reason being to produce deuterium-depleted water,” Seneff says. “It’s all as a result of the mitochondria are failing of their activity of producing their very own deuterium-depleted water, which they get partially by the structured water from the sulfate [and] by enzymes which can be extremely expert at selecting hydrogen over deuterium …
NADH and NADPH are additionally fascinating. I have been chasing them by all of the proteins. They’re attention-grabbing as a result of they’re the carriers of that fantastic hydrogen that is not deuterium. Once you hint what’s doing what, the place, you understand that the cytoplasm is producing NADH and handing it over to the mitochondria.
The mitochondria then take that H [hydrogen atom] off and throw it into the intermembrane area. So, the entire course of finally ends up with the intermembrane area being assured that that is H [hydrogen] and never D [deuterium].
That is essential as a result of then these protons, as soon as they construct up, come again by the ATPase [ATP synthase] pump. If they’re deuterons, they’ll wreck the pump … You launch reactive oxygen species [that] break it, and naturally, then you’ll be able to’t make ATP.”
For clarification, the ATP synthase pump works like a mini-motor. When a hydrogen atom with one proton goes by it, it really works flawlessly and generates ATP. If deuterium enters it, which has one neutron and one proton, making it twice the load of hydrogen, it breaks that motor.
Apparently, deuterium is in every single place, naturally, however your physique has developed an intricate solution to make it innocent by trapping it within the structured water, the place it’s helpful, because it truly helps the creation of structured water.
Issues come up whenever you can not make sufficient structured water to sequester all of it. Then, the deuterium will get unfastened, inflicting mitochondrial dysfunction, impairing power manufacturing and contributing to continual illness.
Glyphosate Damages Well being in Many Methods
As famous by Seneff, glyphosate harms your well being in various methods. For instance, she cites a latest paper displaying it causes endocrine disruption, which can result in breast most cancers, reproductive points, weight problems and thyroid issues.6
One other paper exhibits glyphosate sensitizes cells to be extra receptive to most cancers after publicity to different chemical compounds.7 “Glyphosate makes all the things else extra poisonous than it could in any other case be,” Seneff says. “It disrupts your protection system in opposition to poisonous chemical compounds.” Different analysis exhibits epigenetic and generational results, even when no obvious issues will be discovered within the first era uncovered.8
Glyphosate additionally impairs flavoproteins — proteins that bind flavins. Many of those proteins play an important function in transferring hydrogen from NADH or NADPH to different molecules, basically supporting the supply of pure hydrogen to the mitochondria. Flavoproteins have a attribute GxGxxG motif on the website the place they bind phosphate within the flavins. The ‘G’ stands for glycine and the ‘x’ is a wildcard — any amino acid, together with glycine.
This implies they have not less than three prone glycines at this vital area of the protein. Flavoproteins are molecules that facilitate the switch of protons and electrons, and know how you can keep away from deuterium, by exploiting a particular characteristic of hydrogen referred to as proton tunneling.
All of them can be anticipated to be disrupted by glyphosate. A vital flavoprotein is succinate dehydrogenase, and a number of other papers have proven it’s adversely affected by glyphosate, Seneff says. It’s the solely enzyme that performs a task in each oxidative phosphorylation and the citric acid cycle within the mitochondria.
Along with fragrant amino acids, the shikimate pathway is important for riboflavin synthesis, and riboflavin, a B vitamin, is the principle precursor to flavins. Which means that riboflavin deficiency will be triggered from glyphosate publicity as properly.
Glyphosate additionally causes harm by:
- Growing calcium uptake in cells, which causes toxicity to neurons
- Interfering with the power to take glutamate out of your synapses
- Making manganese unavailable — This in flip disrupts and prevents glutamate from being become unhazardous glutamine after it’s eliminated out of your synapses. The enzyme liable for the conversion can also be extremely depending on glycine, which might be changed by glyphosate
Deuterium-Depleted Water Might Be Central to Metabolism
In keeping with Seneff, it seems deuterium-depleted water performs a central, hitherto unappreciated function in metabolism, as your physique has so some ways to create it. For instance, deuterium-depleted water is created by:
• Fatty acid synthesis and metabolism — The enzymes that synthesize fatty acids incorporate hydrogen that is carried by NADPH. This hydrogen atom has been rigorously chosen to be assured to not be deuterium. Apparently, lipoxygenase is a protein expressed throughout circumstances of stress, and in keeping with Seneff, it has the best capability to pick out protons over deuterons of any protein.
It’s extremely upregulated in extreme COVID-19 an infection. It seems the virus triggers a rise in lipoxygenase as a result of the virus captures linoleic acid (LA) in pockets within the viral membrane. Nevertheless, lipoxygenase is not a flavoprotein, and it additionally doesn’t bind heme — this makes it immune to harm from glyphosate. So, its activation turns into an alternate pathway to repair the mitochondrial deuterium downside.
SARS-CoV-2 picks up the omega-6 LA because it crosses the mobile membrane, and the LA then triggers the manufacturing of lipoxygenase that modifies the LA into leukotrienes — signaling molecules that usher in damaging macrophages.
However deuterium-depleted water can also be produced on this course of, by yanking two hydrogen atoms out of the fats and mixing them with oxygen to make water. Notice that that is simply one more means that extra LA damages your physique, however with an ulterior motive that we frequently fail to understand.
• Sterol synthesis and metabolism — together with ldl cholesterol, vitamin D, cortisol, and intercourse hormones.
• Fragrant amino acid derivatives — together with melatonin and neurotransmitters corresponding to dopamine and serotonin, in addition to thyroid hormone.
“All these molecules that undergo these difficult steps are all centered on delivering deuterium-depleted water to the mitochondria,” Seneff says. “I imply, it is an absolute obsession that the cell has.” She goes on to evaluate how processes that might seem to don’t have anything however dangerous results are literally an effort to heal the physique. This, for instance, appears to be the case in COVID-19:
“I imagine that no matter biology is doing, it is doing it for a great purpose. There could also be harm, however there is a good purpose why you want that harm with a purpose to survive long run. It is attempting to repair an issue that is very critical, and that is what I feel is occurring with [SARS-CoV-2].
Not solely does it induce this lipoxygenase, which produces deuterium-depleted water, it then creates this inflammatory atmosphere, which brings within the platelets and the macrophages, the immune cells and the stem cells. All these are having a giant celebration in there in all this fluid that is build up contained in the lungs.
In the meantime, it additionally will increase the manufacturing of hyaluronic acid. Hyaluronic acid is ready to lure deuterium-depleted water. It makes structured water. So, you get structured water contained in the alveoli of the lungs, after which you get fluid water within the interstitial areas.
The blood vessels are leaky, the capillaries are leaky. Every thing’s popping out of the capillaries into this interstitial area the place there’s this fluid water, and you have this lipoxygenase making deuterium-depleted water.
So, you are producing this atmosphere of deuterium-depleted water, inviting the macrophages to return in, and the platelets launch their mitochondria … the stem cells additionally are available in and launch their mitochondria, and then macrophages sweep up the mitochondria — and all that is occurring within the interstitial area within the lungs the place the fluid is. That is why you can’t breathe. You are drowning.
Possibly one of the crucial necessary issues platelets do is cling on to mitochondria that they’ll ship to the macrophages beneath circumstances of stress. So, what occurs is all these mitochondria get launched in that interstitial area, and the macrophages induce this macropinocytosis, the place they really sweep up the water and all the things that is in it and convey it contained in the macrophage, together with the mitochondria.
It is truly been proven that platelets can launch mitochondria into the atmosphere, and macrophages can take them up and use them as completely functioning mitochondria. It is astonishing. So, what they’re doing is restoring the mitochondrial well being to the immune cells.”
Glyphosate Injury Might Be a Think about Extreme COVID-19
As defined by Seneff, your immune cells are impaired by glyphosate, so the older you’re, the extra probably you’ve been uncovered to glyphosate for many years and due to this fact have poorly functioning immune cells. Apparently, Seneff factors out that the comorbidities of COVID-19 — weight problems, diabetes and hypertension — are additionally illnesses whose prevalence goes up dramatically over time, precisely in step with glyphosate utilization on core crops.
“So, I feel it is largely about glyphosate,” she says. “Should you’ve amassed a whole lot of glyphosate in your tissues, you are not going to do properly with COVID-19, and that is as a result of [your body] is attempting to restore the mitochondria within the immune cells in order that the immune cells can truly clear the virus. If they cannot make ATP, they cannot do their job, and the virus prospers.”
The important thing take-home message right here is that that is but one more reason to scrub up your weight loss plan to be sure you’re not uncovered to glyphosate. It mainly wrecks your immune cells, and the cascading harm that takes place in extreme circumstances of COVID-19 seems to be your physique’s response to salvage or restore these poorly functioning immune cells.
The reply to this downside is, initially, to eat licensed natural meals at any time when attainable. “We cannot purchase it if we will not discover licensed natural, and we have actually seen well being enhancements since we have began doing that,” Seneff says. “I actually swear by it, and I attempt to get all my associates to do the identical. I feel if you’ll be able to remove glyphosate, you’ll be able to actually see nice enhancements in your well being it doesn’t matter what your issues are.” Different dietary suggestions embody consuming/ingesting extra:
Sulfur-containing meals corresponding to natural eggs and seafood
Natural grass fed milk and butter. Butter is likely one of the lowest deuterium meals accessible
Glacier water, which is of course low in deuterium
Animal fat, that are additionally low in deuterium
Probiotics meals corresponding to sauerkraut and apple cider vinegar
To assist “push” glyphosate out of your physique and mitigate its toxicity, you’ll be able to take an affordable glycine complement. I take between 5 and 10 grams a day. It has a light-weight, candy style, so you’ll be able to truly use it as a sweetener.
“It is sensible as a result of it is mainly going to outnumber the glyphosate molecules,” Seneff says. “Bear in mind, glyphosate’s going to compete with glycine in constructing the protein. If there’s a whole lot of glycine round, then it is a lot much less probably that glyphosate will get in there.”